Structural, Antioxidant and Antivarial Studies of C-3-nitrophenyl CALIX[4]resorcinarene

Bohari M Yamin, Hamza M Abosadiya, Siti Aisah Hasbullah, Jumina Jumina


The calix[4]arene derivative C-3-nitrophenylcalix[4]resorcinarene was synthesized by using one-pot reaction of resorcinol with 3-nitrobenzaldehyde in the presence of concentrated HCl. The compound  was characterized by IR, 1H and 13C NMR spectroscopy. X-ray crystallographic study showed that this compound crystallized in a triclinic system with space group of Pī and the unit cell dimensions, a = 10.6143(3) Å ,b = 13.6262(4) Å, c = 14.7971(5) Å, α = 102.813(3)°, β = 110.917(3)°, γ = 90.885(2)°. V= 1938.78(11) Å3 and Z =2. The biological Studies were also investigated. It has a stromg antioxidant property and high antiviral activity against HSV-1 . Cytotoxicity testing on Vero cells showed that it is non-toxic, with a CC50 of more than 0.4 mg/mL. Moderate antibacterial activity.


C-3-nitrophenylcalix[4]resorcinarene, X-ray structural study; Biological Studies.

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Published by INSIGHT - Indonesian Society for Knowledge and Human Development