Protonated 14-membered 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetrazacyclotetradeca-7,14-diene Salts and Their Biological Activity

Abstract

The 14-membered heterocyclic 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetrazacyclotetradeca-7,14-diene, [(Me6[14]N4diene)], salts with structural formula of [(Me6[14]N4diene)]Br2(H2O)2), [(Me6[14]N4diene)Cl2])(H2O)3, Me6[14]N4diene.(ClO4)2, Me6[14]N4diene.(PF6)2¬  and   Me6[14]N4diene.(NO3)2   have been  synthesized without the necessity of a template. The salts were characterized by FTIR, and NMR spectroscopic techniques. X-ray study showed that the macrocyclic cation consists of a pair of protonated amines and azomethine nitrogen atoms located diagonally and opposite to each other. Only the macrocylic bromide and perchlorate salts showed activity against gram-positive E. faecalis and gram-negative E. Coli.